FGF19-amplified HCC

The best available first-line therapy for advanced liver cancer reaches a median survival of nineteen months.1

Around 5% of tumors carry FGF19 amplification, a subtype that does worse and recurs sooner.2

repressesFGF19FGFR4 ·beta-KlothoTumor signalingCYP7A1Bile acidsynthesisrepressesFGF19FGFR4 ·beta-KlothoTumorsignalingCYP7A1Bile acidsynthesis
191
months, median survival on the best available first-line therapy
5%2
of tumors carry FGF19 amplification

This is a cancer with a precise molecular definition and no therapy matched to it. We are closing that gap.

Please note: Zephira Genomics operates in a stealth capacity.

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